Abstract

INFLUENCE OF STEM BARK AQUEOUS EXTRACT OF BAUHINIA VARIEGATA LINN. ON WOUND HEALING IN ALBINO RATS

Rajeev Kumar*, Bhupendra Nath Dwivedy, Anil Bhandari, Rajesh Kumar Nema

ABSTRACT

The basic objective of the present work was to assess the wound healing activity of Bauhinia variegata stem bark by providing better tissue formation and protection against microbial invasion. Various ointments of extracts in various proportions were prepared and subjected for assessment of wound healing activity in diabetic albino rats (Wister strain). Based on the comparison of wound healing activity of various formulations, the formulation comprising of 4% (w/w) aqueous extract of stem bark of Bauhinia variegata found to be superior to that of control and standard formulation. In addition to greater hydroxyproline content found in healed wounds, the formulation also showed formation of epidermis, keratinization, connective tissue, vascular tissue and collagen at greater level as compared to control and standard formulation.

Keywords: bauhinia variegata, wound contraction, hydroxyproline, keratinization, connective tissue.