Abstract

DESIGN, SYNTHESIS AND EVALUATION OF NOVEL INDOLE DERIVATIVES AS ANTIMICROBIAL AND ANTIFUNGAL AGENTS

Ganesh Mhaske*, Shweta Dighe, Bindurani Ram, Amruta Patil, Ashish Chimbalkar

ABSTRACT

A new class of indole and pyrimidine containing series of NSubstituted- 4-(1H-indol-3-yl)-6-methyl-2-oxo-1,2,3,4- tetrahydropyrimidine-5-carbohydrazide U (1-10) were synthesized as per the scheme reported. N-Substituted-furfuryl, 2, 4- dichlorophenyl,and 2-hydroxyphenyl synthesized by formylation of indole. Elemental analysis, FT-IR, 1H-NMR and Mass spectral data supports the structures of synthesized compounds. The synthesized compounds were evaluated to determine antimicrobial activity against E. coli, P. aeroginosa, S .aureus, C. albicans, A. clavatus using cup-plate dilution method and MIC. The correlation of activity with the structure of synthesized derivatives, it has been observed that electron donating groups like hydroxyl (compound no.U-4), hydroxyl and methoxy (compound no.U-6) attached to the phenyl ring increases antimicrobial activity. The compound such as U-5 (R=furfuryl), have shown excellent activity against E. coli and comparable activity against P.aeruginosa.U-2, U-4 has shown promising activity against the S .aureus and less activity against S. Pyrogenus when compared with the results obtained from standard. The synthesized compounds such as U-4 (2-hydroxyphenyl), U-5(R = furfuryl), have shown excellent activity against the standard drug griseofulvin.

Keywords: Indole, Antifungal Activity, Antibacterial Activity, MIC Determination