Abstract

SPECTROPHOTOMETRIC DETERMINATION OF DRUGS BASED ON OXIDATION BY ACIDIC KMnO4

K. Damodar Reddy, B. Vijay Kumar, K. Sayanna & G.Venkateshwalu*

ABSTRACT

Simple and sensitive validated spectrophotometric methods has been developed for the assay of five drugs viz., Alfuzosin(ALF), Esomeprazole(ESO), Ketoralactromethamine(KET), Lomefloxacine (LOM) and Quetiapine(QUE) in pure and pharmaceutical formulations. The proposed methods were based on the oxidation of the drugs by a known excess of potassium permanganate in acidic medium and estimating the unreacted permanganate with amaranth dye at a suitable λmax 520nm. Beer’s law is obeyed in the concentration range of 3 -12, 1.5 – 4.5, 2.5 – 9.5, 1.5 -7.5 and 2.0-14 μg mL-1 for ALF, ESO, KET, LOM and QUE respectively. Different variables affecting the reaction were studied and optimized. The proposed methods were applied successfully to the determination of the examined drugs in pure and pharmaceutical dosage forms with good accuracy and precision.

Keywords: Drugs, Oxidation, Potassium Permanganateand Spectrophotometry