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Abstract

ANTIANGIOGENIC PROPERTIES STEM, LEAF AND FLOWER EXTRACTS OF CALOTROPIS PROCERA IN CHICK CHORIOALLANTOIC MEMBRANE (CAM)

*K. Kalimuthu R.Prabakaran and V. Chinnadurai

ABSTRACT

Calotropis procera is a well-known plant and has been traditionally used for diarrhea, stomatic, sinus fistula, and skin disease, and the leaf part is used to treat jaundice. The present study deals with analysis of the antiangiogenic properties of C.procera extracts by chick Chorioallantoic Membrane (CAM) assay in vivo. Among the different parts used, methanolic leaf extract showed the higher angiogenic activity followed by methanolic flower extract. The CAM treated with methanolic leaf extract and methanolic flower extracts showed distorted vascularization. The percentage of inhibition in methanolic leaf extract treated CAM was 63.83±1.94 while that in methanolic flower extract was 54.27 ±3.67 followed by methanolic stem extract (28.16±1.16). In methanolic extracts of C. procera leaf, stem and flower when compared to ethanolic extracts.

Keywords: Calotropis procera, leaf, stem and flower.


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