Abstract

A REVIEW ON NASAL DRUG DELIVERY SYSTEM

Aishwarya J Jadhav*, Sheetal B Gondkar, Ravindra B Saudagar

ABSTRACT

There are several routes of drug administration such as oral, transdermal, parenteral, rectal, ocular, intra-vaginal, nasal etc. Amongst them nasal drug delivery shows great impact. Recently, it has been shown that many drugs have better bioavailability by nasal route than by oral route because it has been attributed to rich vasculature and a highly permeable structure of the nasal mucosa. Intranasal route of administration shows potential for delivery of drugs to brain. The noseto- brain drug delivery of drugs is advantageous as it requires low dose of drug, avoids first pass effect. Also it is fast in action and suitable for the drugs that degrade in gastrointestinal tract. However, the major limitation with nasal route administration is the poor contact of the formulations with the nasal mucosa due to mucoceliary clearance. Many attempts have been done in the recent past to increase the residence time of drug formulations in the nasal cavity, resulting in improved nasal drug absorption by using mucoadhesive polymers.

Keywords: Nasal drug delivery, Insitu gel, polymers used in gel preparation, mucoadhesive polymer.