Abstract

IMPACT OF OXIDATIVE STRESS IN DEVELOPMENT OF DIABETIC RETINOPATHY AND ANTIOXIDANTS AS TREATMENT OPTION

Bhatt Sonia, Kumar Sandeep*, Sharma Niti, Chauhan Neelam

ABSTRACT

Diabetes mellitus is one of the most common diseases around the world and is responsible for many deaths. Constant hyperglycemia may lead to some of very serious complications like Diabetic Neuropathy and Diabetic Retinopathy along with some other complications. There is a constant quest for newer and better medication which may improve the quality of life for diabetic patients. Recently the role of oxidative stress has been identified in pathogenesis of diabetic complications including Diabetic Retinopathy(DR).The present work is an attempt to explore the biochemical mechanisms through which over production of oxidants may result in Diabetic Retinopathy. The antioxidants which have been used in diabetic animal models and human models are compiled here to get better understanding. Moreover this work will help researchers to decide their future directions in mitigations of diabetic retinopathy.

Keywords: Diabetic Retinopathy, Hyperglycemia, Antioxidants, Superoxide, Protein KinaseC, Nitrotyrosine.