Abstract

EFFECT OF PADDY HUSK EXTRACTS ON GLUCOSE TOLERANCE IN GLUCOSE-INDUCED HYPERGLYCEMIC MICE

Shahnaz Rahman, Rownak Jahan, Mohammed Rahmatullah*

ABSTRACT

ABSTRACT Background. Paddy husks are the by-products produced in the paddy milling industry and are usually discarded or burnt. Yet, the husk is rich in compounds like ferulic, vanillic and p-coumaric acids, which have good antioxidant capacities. Diabetes mellitus is becoming almost endemic throughout the world, and oxidative stress has been said to play a major role in diabetes associated hyperglycemia and other complications. It was the objective of this study to evaluate the antihyperglycemic potential of various solvent extracts of paddy husk. Methods. Oral glucose tolerance test (OGTT) was used to determine antihyperglycemic activity. Methanol (MEPH), ethanol (EEPH), and an alkali-soluble (ASPH) extract of paddy husks were evaluated.Results. Administration of MEPH, EEPH, and ASPH led to dose- dependent and significant reductions in blood glucose levels in glucose-loaded mice. At doses of 50, 100, 200 and 400 mg per kg body weight, MEPH reduced blood glucose levels by 36.8, 41.0, 56.4, and 58.6%, respectively compared to control animals. At the same extract doses, EEPH reduced blood glucose levels by 21.9, 35.0, 42.4, and 51.8%. ASPH at the same doses reduced blood glucose levels by 20.9, 37.9, 43.2, and 50.8%. By comparison, a standard antihyperglycemic drug, glibenclamide, when administered at a dose of 10 mg per kg body weight, reduced blood glucose level by 53.5%. Conclusion. Antihyperglycemic activities have not previously been reported for paddy husk. Since husks are widely available in Bangladesh, they can be a good source for isolation of bioactive compounds towards lowering blood sugar in diabetic patients.

Keywords: Antihyperglycemic, paddy, husk, OGTT, Poaceae