Abstract

A REVIEW ON BERBAMINE – A POTENTIAL ANTICANCER DRUG

Mohammed Rahmatullah*, Rownak Jahan, A.B.M. Anwarul Bashar, Abdullah Al-Nahain, Snehali Majumder, Md Tabibul Islam, Protiva Rani Das

ABSTRACT

Berbamine belongs to the bisbenzylisoquinoline group of alkaloids and is present in a number of plant species belonging to the Berberis genus within the Berberidaceae family. The compound and various synthetic derivatives of the compound have shown remarkable success in in vitro trials to reduce cell viability and induce apoptosis in a number of cell lines obtained from a diverse variety of cancers. In this review, we explore the various studies conducted with berbamine and its derivatives and the possible molecular mechanisms behind their anticancer activities.

Keywords: Berbamine, Berberis, Berberidaceae, anticancer