Abstract

ANTI HEPATOTOXICITY STUDIES OF CRUDE EXTRACT OF FERONIA LIMONIA IN CCL4 INDUCED TOXICITY

Jayashree V Hanchinalmath and Ramesh Londonkar*

ABSTRACT

The antioxidant activities of Feronia limonia fruit pulp methanolic extract (MEFL) was investigated by and in vivo assay. The effect of the extract in reducing carbon tetrachloride induced (CCl4) oxidative stress in rats was evaluated. Hepatoprotective activity of MEFL was studied by estimating serum enzyme activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), Serum Lactate Dehydrogenase (LDH), total protein (TP) and total bilirubin (TB). The treatment with MEFL showed a dose-dependent reduction in CCl4 induced elevated serum levels of enzyme activities with parallel increase in total protein and bilirubin content indicating the extract could preserve the normal functional status of the liver. MEFL at the doses of 200 and 400 mg/kg body weight significantly increased the glutathione (GSH), super oxide dismutase (SOD) and catalase (CAT) activities in a dose dependant manner. Therefore, the results of this study illustrate that the Feronia limonia methanol extract can shield the liver against CCl4-induced oxidative damage in rats.

Keywords: Feronia limonia, antioxidant activity, phenolic content, CCl4.