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Abstract

SYNTHESIS, CHARACTERIZATION AND EVALUATION OF SOME CYANOPYRIDINE DERIVATIVES

T.Rajkumar *, S.Paramesh, B.Ramesh, G.Pushapalatha, K.Bharathi & C.Ramesh

ABSTRACT

A new series of Cyanopyridine derivatives were synthesized by condensing chalcones with malononitrile. First Chalcones were prepared by treatment of various acetophenone derivatives with different aromatic aldehydes by Claisen-Schimidt Condensation and then refluxed with malononitrile to obtain cyanopyridines .All the compounds were screened for their antitubercular and anthelmintic activities. The structures of newly synthesized compounds were characterized on the basis of IR, 1H NMR and Mass spectral data.

Keywords: Cyanopyridine; Chalcone; Antitubercular activity; Anthelmintic activity


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