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Abstract

ORALLY DISINTEGRATING TABLETS; A DOSAGE FORM THAT EXTENDS THE MARKET EXCLUSIVITY AND PATENT PROTECTION

Shiv Kumar Srivastava* Ravendra Verma, Vikash Chandra,Shobhit Prakash Srivastava

ABSTRACT

Orally Disintegrating Tablet (ODT) is a solid unit dosage form containing drugs that disintegrates rapidly and dissolves in the mouth without taking water within 60seconds or less. It ishighly acceptable due to good patient compliance along with improved bioavailability from the manufacturers view. There are many challenges during formulation of ODTs like palatability, mouth feel, grittiness of particles, size and strength of tablet. ODT can be prepared by many technologies like lyophilization, molding, spray drying,cotton candy and compression etc., but among these technologies direct compression is most convenient and cheap way to produce tablets with sufficient structural integrity. This dosage form may be used for protein and peptide based drug delivery system in the future and Controlled release ODTs can also prepared by using different drug carriers.

Keywords: ODTs, Lyophilization, Direct Compression, Ac-Di-Sol, Pregastric.


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