THE ASSOCIATION OF OXIDIZED HIGH DENSITY LIPOPROTEIN AND OXIDIZED NON-HIGH DENSITY LIPOPROTEIN WITH THE DEVELOPMENT OF MICROALBUMINURIA IN DIABETIC NEPHROPATHY
Mohammed A. Al-Bayati, Dina A. Jamil, Hayder A. Al-Aubaidy*
ABSTRACT
This study was undertaken to investigate the association of total lipid
peroxides and oxidized HDL in the progression of microalbuminuria in
diabetic nephropathy. Fifty-five patients with type 2 diabetes mellitus
were recruited in this study and were divided into 2 main groups based
on the presence of microalbuminuria, the first group
(microalbuminuric group n=31) had a microalbuminuria between 30-
299 ug/mg. The second group (normoalbuminuric group, n=29) had an
albumin level less than 30 ug/mg. The two diabetic groups were
compared to the control group (n=37). The results of our study showed significant elevation in
the levels of serum lipid profiles and lipid peroxidation markers in the microalbuminuric
group compared to the normoalbuminuric group at P<0.001. This was associated with
significant changes in these markers between the normoalbuminuric group and the control
group. In addition, there was also significant changes in the level of these markers in the
microalbuminuric group compared to the normoalbuminuric group at P<0.001. The current
study illustrates that the presence of microalbuminuria in type 2 DM can be regarded as an
index of increased cardiovascular vulnerability and a signal for vigorous efforts at correction
of the known risk factors to avoid the progression of diabetic nephropathy.
Keywords: Serum lipids, lipid peroxidation, microalbuminuria, type 2 diabetes mellitus.
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