Abstract

ASSOCIATION OF LIFESTYLE VARIABLES WITH THE NOVEL MUTATION OF BRCA1 GENE IN BREAST CANCER: A CASECONTROL STUDY AMONG THE BENGALEE HINDU FEMALES OF WEST BENGAL, INDIA.

Abhishikta Ghosh Roy*, Pulakes Purkait, Malay Barman, Biswanath Sarkar and Arup Ratan Bandyopadhyay

ABSTRACT

BRCA1 mutations dramatically increase breast cancer risk, which is the commonest cause of female death globally including India. There is a substantial inter-individual variability in breast cancer risk among BRCA1 mutation carriers, which attracts attention of medical genetics. In the present study we have identified a novel mutation (cd.1437 CCT>CTT) in BRCA1 gene that changes the amino acid from Proline to Leucine. Certain lifestyle factors like oral contraceptive use and abortions are found to be highly associated with breast cancer risk among the carriers of germline mutation. This study is the first report from West Bengal among the Bengalee Hindu Caste Female Breast Cancer patients, which would help in early prognosis of the mutation and modification of lifestyle factors.

Keywords: Novel Mutation, Breast Cancer, Lifestyle factors, Bengalee Hindu females, West Bengal, India.