ANTIVIRAL AND ANTIMICROBIAL ACTIVITIES OF SPIRULINA PLATENSIS
Mona Hetta*, Rehab Mahmoud, Waled El-Senousy, Mohamed Ibrahim ,Gamila El-Taweel, Gamila Ali
ABSTRACT
The total crude (70%) methanol extract and five successive extracts of
Spirulina platensis were tested against four types of viruses using cell
viability assay and nine strains of Gram (+ve) and Gram (-ve) bacteria
as well as Candida albicans using disc diffusion method. The results
revealed that the total methanol and n-hexane extracts were
significantly active against all tested viruses showing mean %
inhibition of 56.7% and 66.7% against rotavirus Wa strain; 60% and
63.3% against adenovirus type 7; 53.3% and 50% against adenovirus
type 40 respectively and 50% for both extracts against Coxsackievirus
B4. The ethyl acetate extractive was active only against rotavirus Wa
strain with 53.3% inhibition. Normal hexane extract was most potent against Salmonella
senftenberg with 58.5% inhibition. GC-MS analysis of the saponifiable and unsaponifiable
fractions of the n-hexane extract besides the total carbohydrate, phenolic, flavonoid and
tannin contents of the crude methanol extract were carried out.
Keywords: Spirulina platensis, antiviral, antimicrobial, chemical components.
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