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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript

Call for Paper

WJPPS Invited to submit your valuable manuscripts for Coming Issue.

Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

New Impact Factor

WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

Scope Indexed

WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

WJPPS: APRIL ISSUE PUBLISHED

April Issue has been successfully launched on 1 April 2024.

Abstract

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NOVEL 2-SUBSTITUTED BENZIMIDAZOLE SCHIFF BASES AND ITS AZETIDINONE AND THIAZOLIDINONE DERIVATIVES

*Abhay Kumar Verma*, Rashmi kumari, Arun Kumar Singh (Sr.), Rinky Maurya ,Mukesh Chandra Sharma.

ABSTRACT

In the present study, a new series of 2-substituted benzimidazole schiff bases and its azetidinone and thiazolidinone derivatives were synthesized from O-phenylenediamine and P-amino benzoic acid. The synthesized compounds were screened for antibacterial (Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Salmonella typhi), antifungal (Candida albicans and Aspergillus niger), analgesic activity by tail-flick method and anti-inflammatory activity by carrageenan induced paw oedema method. The synthesized compounds showed significant activity of antibacterial, antifungal, analgesic and anti-inflammatory activity comparable to that of standard.

Keywords: Benzimidazole, Azetidinone, Thiazolidinone, Antibacterial, Antifungal, Analgesic, Anti-inflammatory.

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