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Abstract

EVALUATION OF ANTICANCER ACTIVITY OF METHANOLIC EXTRACT OF CARALLUMA FIMBRIATA WALL. AGAINST LUNG CANCER CELL LINE

Priya D*, Rajaram K*, Sureshkumar P

ABSTRACT

The present study is designed to evaluate the in-vitro anticancer activity of methanolic extract of Caralluma fimbriata Wall. against Lung cancer cell line A-549 for its effects on cell viability, growth inhibition and cell morphology. Cell viability and inhibition was determined by cytotoxicity assay and MTT assay. Cell morphology was observed under inverted microscope. The cytotoxicity effect of Methanol extract carried out using various concentration in L6 muscle cells. The result showed that the methanol extract upto 100μg/ml having lesser toxicity. Hence the doses for antiproliferative activity fixed within that concentration. The antiproliferative results showed decreased cell viability and increased growth inhibition in a dose and duration dependent manner and also altered cell morphology after treatment with methanolic extract of Caralluma fimbriata Wall. The data demonstrated that methanolic extracts of Caralluma fimbriata Wall. has a potential anticancer agent on A-549.

Keywords: Caralluma fimbriata Wall., Anticancer, cytotoxic, 3-(4,5-dimethylthiazol-2-yl)- 2,5- diphenyltetrazolium bromide (MTT) assay, A-549 and L6 cell line.


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