Abstract

COMPUTER ASSISTED DESIGNING (CADD), IN SILICO PHARMACOLOGICAL AND IN VITRO STUDIES OF A SERIES OF AZOMETHINE DERIVATIVES OF A SEMI SYNTHETIC AMINOPENICILLIN (AMPICILLIN)

*Abhilash Mullasseril

ABSTRACT

The drug designing and discovery field is one of the most advancing areas of research in the field of medicinal Chemistry. The incorporation of computers and software to the field of research recently attracted the interests of many researchers to this fast growing field of research. One of the challenging research problems by the scientists is the enhanced drug resistances shown by common pathogens those were previously susceptible to many of the drugs including many of the β-Lactams. It is not advisable to develop a specific drug for specific pathogen each time to overcome this challenging problem due to lack of time and the huge expenses needed for research. One of the easiest possible solutions is the derivatization of the presently prescribing drugs at their possible sites by strictly adhering to governing rules. In this research paper application of Computer Assisted Drug Designing (CADD), In silico QSAR studies, Synthesis and characterization, systematic in vitro antibacterial screening of a series of azomethine derivatives of leadingly prescribing aminopenicillin (ampicillin) etc. are achieved in an interesting manner to demonstrate the practical solution that can be adopted for drug discovery processes.

Keywords: Computer Assisted Drug Designing (CADD), In silico QSAR Studies, Ampicillin, Docking, ?-Lactams and ?-Lactamases, Lipinski rules.