Abstract

BRIEF INTRODUCTION ON FLOATING DRUG DELIVERY SYSTEM (FDDS): AN APPROACH FOR CONTROLLED DRUG DELIVERY

*Rajesh R. Satani¹, Dhaval J. Sankaliya¹, Hrushikesh L. Koria²

ABSTRACT

The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. It is known that differences in gastric physiology (such as, gastric pH, motility) exhibit both intra- as well as inter-subject variability demonstrating significant impact on gastric retention time and drug delivery behaviour. Gastric emptying is a complex process and makes in vivo performance of the drug delivery systems uncertain. In order to avoid this variability, efforts have been made to increase the retention time of the drug-delivery systems for more than 12 hours. The floating or hydrodynamically controlled drug delivery systems are useful in such application. From the formulation and technological point of view, the floating drug delivery system is comparatively easy and logical approach.

Keywords: Floating drug delivery system, single unit, multiple unit, evaluation and applications.