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Abstract

STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF PARACETAMOL AND PAMABROM IN BULK AND COMBINED PHARMACEUTICAL DOSAGE FORM

Dhruvi Shah*, Bhagirath Patel, Ankita Bhavsar

ABSTRACT

A simple stability indicating high-performance liquid chromatographic method was developed and validated for simultaneous estimation of Paracetamol and Pamabrom in bulk and combined pharmaceutical dosage form. Reversed-phase chromatography was performed on Shimadzu Model SPD-20AT, using a mixture of Phosphate buffer: Methanol (65:35v/v) as a mobile phase with a flow rate of 1.0 ml/min. Detection wavelength was selected 270nm. The retention time for Paracetamol and Pamabrom was found to be 4.04 min and 7.36 min respectively. The linearity of developed method was achieved in the range of 32.5-97.5μg/ml for Paracetamol and 2.5-7.5μg/ml for Pamabrom. The Paracetamol and Pamabrom were subjected to stress conditions including acidic, alkaline, oxidation, thermal and sunlight degradation. The method was validated as per ICH guidelines.

Keywords: RP-HPLC, Stability indicating method, Paracetamol (PCM), Pamabrom (PAM).


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