FORMULATION AND IN VITRO EVALUATION OF MICROPARTICLE CARRIER CONTAINING MEFENAMIC ACID
Anudeep Balla*, Dr. Shivanand Kalyanappa, Haarika Maddineni, Ashvini H.M
ABSTRACT
Main aim of the present study was to prepare and characterize
Mefenamic acid (MA) microspheres using Ethylcellulose and Eudragit
RL100 as polymers by emulsion solvent evaporation method. The
influence of type and concentration of polymers on retarding the drug
release was tested. The resultant microspheres were evaluated for
percentage yield, drug entrapment efficiency, micromeritic properties,
in-vitro drug release studies and release kinetics. Results indicated that
the percentage yield, drug entrapment efficiency, micromeritic
properties of microparticles were influenced by varying drug and
polymers ratio. The release rate of microparticles could be controlled
by adjusting the combination of polymers and their ratios. IR
spectroscopy and DSC studies confirmed the absence of any drug polymer interaction and
further characterized by scanning electron microscopy (SEM). The in-vitro release profiles
from microparticles were fitted into various kinetic models and the best fit with the highest
correlation coefficient was observed in zero order plot, indicating that the predominant
release mechanism was controlled release.
Keywords: Mefenamic acid; Ethylcellulose; Eudragit RL 100; release rate.
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