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Abstract

EVALUATION OF ACUTE ORAL TOXICITY OF NIGELLA SATIVA LINN SEED METHANOLIC EXTRACT IN MICE

Imtiyaz Ahmad*, Jagrati Tripathi, Manik Sharma, Amit Nayak

ABSTRACT

Nigella sativaL. is widely used in traditional medicine to treat various types of ailments and has been described as the future of pharmacology.The evaluation of toxic properties of N. sativa L.is crucial when considering public health protection because exposure to plant extracts can result in undesirable effects on consumers. Modern regulatory systems contain extensive requirements for safety testing of new chemical products before they enter the stream of commerce. Hence, in this study the acute oral toxicity of N. sativa L. seeds extract was investigated in mice. Oral administration of crude extract at the highest dose of 2000 mg/kg resulted in no mortalities or evidence of adverse effects, implying that N. sativa L. seed extract is nontoxic. Throughout 14 days of the treatment no changes in behavioral pattern, clinical sign and body weight of mice in both control and treatment groups. Also macroscopic examination of the organs of the animals treated with extract showed no changes in color. Overall, the results suggest that, the oral administration of N. sativa L. seedmethanolic extract did not produce any significant toxic effect in mice.Further, examination revealed normal architecture and no significant adverse effects observed on the kidney, heart, liver, lung and spleen. Hence, theextract can be utilized for pharmaceutical formulations.

Keywords: Nigella sativa L, Oral toxicity, organ weight, methanol extract.


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