SYNTHESIS, CHARACTERISATION & ANTIBACTERIAL ACTIVITY OF NEW FATTY ACID THIOSEMICARBAZIDE FROM CANNABIS SATIVA (HEMP) SEED OIL
*Shobha S. Borhade
ABSTRACT
Thiosemicarbazone derivative are of special importance because of
their versatile biological and pharmacological activities. It is potential
intermediate for the synthesis of pharmaceutical and bioactive
materials and used in the field of medicinal chemistry. Hemp seed oil
is bold yellow coloured slightly viscous liquid. It has high iodine value
indicate higher content of fatty acid. Fatty acids are important to every
cell in the body for normal growth. Technically a nut, hempseed
typically contains over 30% oil and about 25% protein, with
considerable amounts of dietary fiber, vitamins and minerals.
Hempseed oil is over 80% in polyunsaturated fatty acids (PUFAs), and
is an exceptionally rich source of the two essential fatty acids (EFAs) linoleic acid (18:2
omega-6) and alpha-linolenic acid (18:3 omega-3). The omega-6 to omega-3 ratio (n6/n3) in
hempseed oil is normally between 2:1 and 3:1, which is considered to be optimal for human
health. Hempseed is an excellent source of nutrition. Fatty acid thiosemicarbazide of
Cannabis sativa ( Hemp) Seed oil was synthesized.The infrared spectra and X-ray diffraction
of of fatty acidthiosemicarbazide was studied . The antibacterial activity of fatty acid
thiosemicarbazide was evaluated. The bacteria B.cerus,E.coli and S.aureus was found to be
more active.
Keywords: Cannabis sativa ( Hemp) Seed oil, Thiosemicarbazide Antimicrobial sample, IR,X-RD.
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