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Abstract

SYNTHESIS, CHARACTERISATION & ANTIBACTERIAL ACTIVITY OF NEW FATTY ACID THIOSEMICARBAZIDE FROM CANNABIS SATIVA (HEMP) SEED OIL

*Shobha S. Borhade

ABSTRACT

Thiosemicarbazone derivative are of special importance because of their versatile biological and pharmacological activities. It is potential intermediate for the synthesis of pharmaceutical and bioactive materials and used in the field of medicinal chemistry. Hemp seed oil is bold yellow coloured slightly viscous liquid. It has high iodine value indicate higher content of fatty acid. Fatty acids are important to every cell in the body for normal growth. Technically a nut, hempseed typically contains over 30% oil and about 25% protein, with considerable amounts of dietary fiber, vitamins and minerals. Hempseed oil is over 80% in polyunsaturated fatty acids (PUFAs), and is an exceptionally rich source of the two essential fatty acids (EFAs) linoleic acid (18:2 omega-6) and alpha-linolenic acid (18:3 omega-3). The omega-6 to omega-3 ratio (n6/n3) in hempseed oil is normally between 2:1 and 3:1, which is considered to be optimal for human health. Hempseed is an excellent source of nutrition. Fatty acid thiosemicarbazide of Cannabis sativa ( Hemp) Seed oil was synthesized.The infrared spectra and X-ray diffraction of of fatty acidthiosemicarbazide was studied . The antibacterial activity of fatty acid thiosemicarbazide was evaluated. The bacteria B.cerus,E.coli and S.aureus was found to be more active.

Keywords: Cannabis sativa ( Hemp) Seed oil, Thiosemicarbazide Antimicrobial sample, IR,X-RD.


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