FORMULATION AND EVALUATION OF COLON SPECIFIC DRUG DELIVERY SYSTEM OF ZALTOPROFEN
Pramod D. Mahajan*, Dr. Surajj M. Sarode, Prof. Bhushankumar S. Sathe,Dr. Parag V. Jain, Bharat. V. Jain, Dr. Gautam.P. Vadnere
ABSTRACT
Compression coating is one of the strategies for delivering drug to the
colon based on Gastrointestinal PH & transit time concept. The main
aim of these formulations to develop rapidly disintegrating Zaltoprofen
core tablets compression-coated with a mixture of time dependent
hydrophilic swellable polymer HPMC K 15 and PH responsive soluble
polymer Chitosan & Guar gum in different ratios. The effect of
proportion of HPMC, Chitosan and Guar gum in the coat on premature
drug release in upper part (Stomach and small intestine) of GIT & the
amount of drug release in colon target area was studied. The
formulations are carried out by using Direct Compression method.
Sodium starch Glycolate used for rapid disintegration. FTIR used for Drug-Polymer
Interaction studies. The prepare tablets were evaluated for hardness, thickness, friability, invitro
disintegration, In-Vitro Dissolution and In-Vitro kinetic study. The F2 Batch Guar gum
gives better result than other formulations.
Keywords: Zaltoprofen, Chitosan, HPMC K 15, Guar Gum.
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