ENHANCEMENT OF DISSOLUTION RATE OF FENOFIBRATE BY USING VARIOUS SOLID DISPERSION TECHNIQUES
Brahmaiah Bonthagarala*, Sreekanth Nama, Suresh Nuthakki, Katta Vamshi Kiran ,Prasanth Pasumarthi
ABSTRACT
The aim of the present research work, Fenofibrate a BCS class II Antihyperlipidemic
drug belongs to fibrate class was formulated as solid
dispersions by using various hydrophilic carriers to enhance the
solubility, dissolution rate and oral bioavailability. Kneading technique
is used to prepare solid dispersions of fenofibrate. Solid state
characterization of solid dispersions is done by Differential Scanning
Calorimetry, Fourier-Transform Infrared spectrometry and X-ray
powder Diffraction studies, Scanning electron microscopy. The solid
dispersions can be evaluated by in-vitro dissolution studies. To develop
the solid oral dosage form (Tablets) with fenofibrate solid dispersions.
To study the physical parameters of tablets prepared by direct
compression, which includes hardness, friability, weight variation, and
disintegration. To estimate the % drug content in the solid dispersions
and the fabricated formulations. To evaluate the drug release from the tablets by in-vitro
dissolution studies and to compare in-vitro dissolution profile of fabricated formulation with
marketed formulation.
Keywords: Fenofibrate, Hydroxyl propyl ? Cyclodextrin, ? Cyclodextrin, Solid dispersion, BCS class II Anti-hyperlipidemic drug.
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