Abstract

FORMULATION AND EVALUATION OF GLIPIZIDE MICROCAPSULES PREPARED BY NATURAL GUMS AND SYNTHETIC POLYMERS

Latheeshjlal.L*, Dr.Satyanandan, Vaidya Mehul J

ABSTRACT

The GI tract is the most preferred and commonly used route for the delivery of drug. Microencapsulation is a useful method for prolonging drug release from dosage forms and drug targeting. Mucoadhesion has been a topic of interest in the design of drug delivery system to prolong the residence time of the dosage form at the site of absorption to improve and enhance the bioavailability of drugs. Glipizide is an oral hypoglycemic agent, which is a commonly prescribed drug for the treatment of patients with type II diabetes. The main objective of the present study was to prepare and evaluate Glipizide Mucoadhesive microcapsules by Emulsification Gelation process. The microcapsules were evaluated for flow properties, Carr’s index, hausner ratio, micro encapsulation efficiency, drug release characteristics, and surface characteristics; compatibility studies and mucoadhesive properties. Sharp endothermic peaks were noticed from the microcapsules formulated 215ºC indicating the compatibility between the drug and the polymer. In-vitro studies showed that Glipizide release from the Microcapsules was slow, spread over extended period of time which is depend on the coat:core ratio. Microcapsules prepared by 5:1 ratio were subjected to comparative studies. A significant difference in the permeability coefficient was observed between. In-vitro release studies shows the microcapsules prepared by Gum Kondagogu was in controlled manner when compare to other polymers used. Invitro wash off test shows the microcapsules prepared by Gum Kondagogu had good mucoadhesive potency than the microcapsules prepared by other polymers used. Correlation coefficient (R) value was used to choose the best model to describe the drug release and it showed the R value was high in zero order models than other models. It indicates the microcapsules followed zero order kinetics. The drug release mechanism from the microcapsules was Non fickian transport as n value is in between 0.69 to 1.12 This study clearly demonstrated that the microcapsules prepared by Gum Kondagogu are, thus, suitable for oral controlled release of glipizide

Keywords: Emulsification Gelation process, Glipizide, Gum kondagogu, Gum Karaya, HPMC, Carbopol.