Abstract

HISTOLOGICAL EVALUATION OF TESTICULAR BIOPSIES AND SPERMATOGENESIS DISTURBANCE IN INFERTILE MEN WITH VARICOCELE

*Dr.Chandra Philip X, Dr.Arun Kumar Bilodi, Dr.S.Joseph Philipraj

ABSTRACT

Reproduction (or making a baby) is a simple and natural experience formost couples. However, for some couples it is very difficult toconceive. Infertility is a disease of the reproductive system defined bythe failure to achieve a clinical pregnancy after 12 months or more ofregular unprotected sexual intercourse. It is also defined as the inabilityof a sexually active, non-contracepting couple to achieve pregnancy inone year. Infertility is a widespread problem. For about one in fiveinfertile couples the problem lies solely in the male partner (maleinfertility). The male partner can be evaluated for infertility orsubfertility using a variety of clinical interventions, and also from aclaboratory evaluation of semen. Varicocele is the most common cause of maleinfertility.cHisto-pathological evaluations of 68 testicular biopsies from infertile men werecarried out. Histological changes were correlated with sperm count. Hypo spermatogenesis(80.88%) with sloughing was the commonest histological pattern observed in the presentstudy, followed by normal spermatogenesis (5.88%) and maturation arrest (5.88%).Sertoli cell only syndrome was observed in 1.47% of cases. Most of the patients were in theage group of 31 to 40 years.

Keywords: Varicocele , Infertility , Testicular biopsy , Spermatogenesis.