Abstract

FORMULATION AND DEVELOPMENT OF TABLETS SOLID DISPERSIONS USING FELODIPINE AS MODEL DRUG

Shubhrajit Mantry*,  Farha Amna Shaik, Srikanth, S.Anil Kumar

ABSTRACT

The purpose of the study to carried out solid dispersions using felodipine as model drug. Solid dispersions of felodipine were prepared by solvent evaporation method using three polymeric carriers. The dissolution rate of formulations was markedly increased as compared to the pure drug. Use of hydrophilic carriers such as PVP K- 30, PEG 4000 and PEG 6000 in the preparation of solid dispersion enhances the solubility of poorly water soluble felodipine with high dissolution rate. The solubility of felodipine was found to be increased with increase of carrier amount up to the ratio of 1:3 for PVP K30 and 1:5 for both PEG 6000 and PEG 4000. Solid dispersions with PVP K30 reveals that there is no significant difference in the dissolution behavior between formulations F3 , F4, F5 & F6. So f3 formulation i.e. (1:3) can be chosen as best because further increase in carrier is unnecessary for formulation. For solid dispersion with PEG 6000 the best formulation was F11 (1:5). For PEG 4000 the best formulation was to be F17 (1:5).

Keywords: Felodipine, Solid Dispersions, PVP K-30, PEG 4000 and PEG 6000.