REVIEW ON-RHEUMATOID ARTHRITIS
Saba Shaikh*, Ravi Dubey, Dr.Y.M Joshi and Dr. Vilasrao J. Kadam
Department of Pharmacology, Bharati Vidyapeeth’s College of Pharmacy, Sector 8, C.B.D., Belapur, Navi Mumbai 400614, Maharashtra, India.
ABSTRACT
Rheumatoid arthritis (RA) is an autoimmune disease that causes
chronic inflammation of the joints. Rheumatoid arthritis can also
cause inflammation of the tissue around the joints,as well as in other
organs in the body.Anti‐cyclic citrullinated peptide antibodies, IgM
and IgA rheumatoid factors are involve in the diagnosis and prognosis
of rheumatoid arthritis.RA traditionally been treated using pyramid
approach,in which non-steroidal anti-inflammatory (NSAIDs) are the
first line treatment and disease modifying anti-rheumatic drugs
(DMARDs) are introduced relatively late in the disease.The treatment
of RA has been revolutionized by advances in the understanding of its
pathologic mechanisms and the development of drugs which target
them.Biologic therapies have provided clear advance in the treatment
of rheumatological conditions.Currently available TNF-targeting
biologic agents that are licensed for at least one of the above-named
diseases are etanercept, infliximab, adalimumab, golimumab, and certolizumab.Biologic
agents with a different mechanism of action have also been approved in rheumatoid arthritis
(rituximab, abatacept, and tocilizumab).Although these biologic agents are highly
effective,there is a need for improved management strategies. Researchers are also
developing molecules–for example,the Janus kinase inhibitor CP-690550 (tofacitinib) to
target other aspects of the inflammatory cascade.
Keywords: Rheumatoid arthritis, Biologic therapy, DMARDs, Kinase inhibitor,TNF inhibitors.
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