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Abstract

ANTI DEPRESSANT ACTIVITY OF ETHANOLIC EXTRACT OF DENDROPTHOE FALCATA LINN IN MICE

P. R. Logesh Kumar*, E. Santhosh Kumar, S. Prasanna, P. Gopalsamy, Dhana Swetha and S. Gnanapriya

ABSTRACT

The objective was to investigate the anti depressant activity of ethanolic extract of Dendropthoe Falcata Linn [EEDF] in albino mice. In this studys rats were separated into 4 groups 1st group was denoted as control group in which only distilled water was used, 2nd group was denoted as standard group in which desimpramine hydrochloric acid [20mg/kg] was used as standard and rest 2 groups were denoted as test groups [T1, T2]. Two doses of the ethanolic extract of dendropthoe falcata [200 and 400 mg/kg] were used as T1 and T2 respectively. Control, standard and test samples [Desimpramine and ethanolic extract of Dendropthoe Falcata] were administered via gavage through oral route [p. o]. The outcomes demonstrated that a dose dependent antidepressant activity FOB and MTD. In the Functional Observational Battery of Drug [FOB] the behaviour of mice can be identified by the effect of the drug. In the determination of MTD [Maximum Tolerance Dose] the early citation and main study were done. The present outcomes obviously show that the EEDF has antidepressant activity in FOB and MTD. The current study could be of therapeutic interest for using in the treatment of patients with depression.

Keywords: Dendropthoe Falcata, Anti-depressant activity, Determination of Maximum Tolerance Dose, Functional observational Battery of Drug.


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