Abstract

APPROACHES OF MICROSPHERES- A REVIEW

K. Malleswari*, D. Rama Brahma Reddy, T. Jabina and V. Dharani Kumari

ABSTRACT

Microspheres are the colloidal drug delivery system. Microspheres are characteristically free-flowing powders consisting of proteins/synthetic polymers that are biodegradable in nature and ideally having a particle size less than 200mm. Biodegradable microspheres can be utilized to direct drugs to certain organs through capillary blockade. Its success depends on the size of the microspheres used and on the mode of administration (intravenous/intra-arterial). The microspheres can also be used for targeting anticancer drugs to the tumor. This review represents the various dimensions and prospective for different areas where microspheres can be used to function as a great drug delivery system. The major categories and types of micro particulate system that can be utilized ranging from radioactive microspheres to floating microspheres for site targeted or sustained release, are being discussed in this review.

Keywords: Microspheres, Methods of Preparation of microspheres, mechanism of microspheres, Evaluation of microspheres.