Photo Gallery

Login

Search

News & Updation

  • WJPPS APRIL ISSUE PUBLISHED
  • APRIL 2019 Issue has been successfully launched on 1 April 2019

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  

Abstract

RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR DETERMINATION OF PENTAZOCINE IN PARENTRAL DOSAGE FORM

D. Rama Brahma Reddy, R. Rajani*, K. Amaravani, K. Soujanya Shalini and K. Mounika and Kenzeuyile

ABSTRACT

A reverse phase isocratic HPLC was developed and validated for the determination of Pentazocine in bulk and parental dosage forms. Method development was carried out on ODS C18 column 250x4.6mm, particle size 5 μm, maintained at ambient temperature, Shimadzu UFLC-LC 20. The mobile phase was a mixture of Methanol: Phosphate Buffer (68:32 v/v), with apparent pH of 3 and the flow rate was set at 1.0 ml/min and UV detection at 285 nm. The chromatographic retention time of proposed method was 3.96 min and the mean assay of content was found to be 99.30%. After completion of chromatographic separation of pentazocine going to do validation of the drug according to USP. The proposed method was successfully applied for the quantitative determination of Pentazocine in bulk form and could be used for routine analysis with phenomenal accuracy and precisions.

Keywords: Pentazocine, Mobile phase, Validation, Accuracy, precision, Retention time.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More