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Abstract

ACUTE TOXICITY AND ANTI-INFLAMMATORY ACTIVITY OF ASPHODELUS MICROCARPUS

Hanae Hosni*, Fatima Zahrae Bellaoui, Amina Bounihi, Yahia Cherrah and Katim Alaoui

ABSTRACT

The aim of this work is to evaluate the acute toxicity and to study the anti-inflammatory effect of the leaves, fruits, and roots of Asphodelus microcarpus. Extraction by cold maceration with methanol was carried out on the different parts of the Am (leaves, fruits, and roots). The extracts obtained were subjected to an acute toxicity study to ensure their innocuousness. This study was carried out in accordance with the OECD guideline 423. Then an evaluation of the anti-inflammatory activity of these three methanolic extracts was carried out by two methods, a chemical method using carrageenan and another physical method by experimental trauma. The results showed that the methanolic extracts from the leaves, fruits, and roots of Am were found to be slightly toxic (with Letal dose for 50% determined at 5000 mg/kg), and they had a significant anti-inflammatory effect from the 200mg/kg dose for all three extracts. The low toxicity and possible anti-inflammatory power of the methanolic extracts from different parts of Am, imply today the need to isolate the active ingredients responsible for this activity in order to confirm the therapeutic interest of the said plant and subsequently propose possible galenic preparations.

Keywords: Asphodelus microcarpus, anti-inflammatory, acute toxicity, carragenan, traumatism.


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