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Abstract

FORMULATION AND EVALUATION OF ORAL DISPERSIBLE TABLETS OF LORATADINE BY DIRECT COMPRESSION METHOD

Surendra Prasad Gupta*, Pashupati Bashyal and Laxmi Shrestha

ABSTRACT

New era is an era of novel drug delivery system. Formulation research is oriented towards increasing safety and efficacy of existing drug molecule through novel concept of drug delivery. Oral dispersible tablet (ODT) has become one of the most widely employed commercial products. Among the various drugs that have potentiality to be formulated in ODT forms, Loratadine is one of them which at present widely applied on the formulation of ODT dosage forms. It is the second generation anti-histamine drug that is widely used in the treatment of rhinitis, hay fever and other various allergic conditions like utricaria and contact dermatitis. It forms the part of initial therapy for allergic reactions. In the present work an attempt has been made to formulate, develop and evaluate oral dispersible tablet of Loratadine by using direct compression method with various superdisintegrants like
sodium starch glycolate, crosscarmellose and crosspovidone, all in different ratios with various tablet ingredients. A total 9 batch (3 batches using each superdisintegrants) were prepared and evaluated for general appearance, physical parameters, drug content and drug release. Along with this, an attempt was made to develop and validate spectrophotometric method for analysis of Loratadine. Formulation (F6) prepared by using crosspovidone in various ratios emerged as the best formulation showed rapid in-vitro disintegration time and drug release by dissolution. Finally it was concluded that oral dispersible tablet of Loratadine can be successfully formulated and will be used as a novel drug dosage form for pediatric and geriatric with improved patient compliance and enhanced bioavailability.

Keywords: Oral Dispersible Tablet, Loratadine, Anti-histamine, Superdisintegrants, Bioavailability.


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