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  • WJPPS APRIL ISSUE PUBLISHED
  • APRIL 2019 Issue has been successfully launched on 1 April 2019

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  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

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Abstract

DEVELOPMENT CAHARACTERIZATION AND EVALUATION OF FORMULATION FOR COLON DELIVERY OF POTENTIAL DRUG

Sachin Devidas Rede*, Sanjay Ravindra Chaudhari

ABSTRACT

The objective of the present study is to prepare microspeheres of Andrographolide and investigate the physiochemical characteristics of the prepare microspheres. The microspheres of Andrographolide with chitosan were formulated using solvent evaporation method. Formulation variables were optimized to prepare microspheres of Andrographolide such as polymer concentration and stabilizer concentration. The effects of these variables on the particle size and entrapment efficiency were studied. The physiochemical characteristics of microspheres were studied applying particles size analysis, zeta potential and Scanning Electron Microscopy analysis. All the prepared formulation resulted in desire size and relative spherical morphology. The zeta potential was remaining in the range of negative value. It represented an index of particle stability. The in vivo toxicity study in Swiss albino mice were carried out, it shown no significant change in biochemical and haematological examination. Hence the designed system could be safe and it will improve the patient compliance.

Keywords: microspeheres, solvent evaporation, zeta potential, particles size analysis.


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