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Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE TABLETS OF RISPERIDONE BY USING SOLID DISPERSION TECHNIQUE

*A. Sambasivarao M.S, Ph.D and M. V. N Mounika

ABSTRACT

The present study was aimed to develop the formulation of sustained release tablets of Risperidone using solid dispersion technique. In this study solid dispersion of the drug were prepared by physical mixtuyre method, Kneading method and Co-precipitate method using Beta cyclodextrine and HP-Beta cyclodextrine and the drug was taken with carrier in the proportions of (1:1 and 1:2). The rate of dissolution of Risperidone was increased with the proportion of (1:2) (Drug: Beta cyclodextrine) Co-precipitate method when compared to the other formulations. The sustained release tablets were prepared by using CP2 formulation. F8 is the better formulation when compared to all formulations. The optimized formulation was subjected to different kinetic models including zero order, first order, Higuchi model and Korsemeyer Peppa’s model and the formulation was found to follow first order release kinetics.

Keywords: Solid dispersions, Sustained release, Risperidone, HPMC K4M, HPMC K15M, HPMC K100M.


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