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  • WJPPS APRIL ISSUE PUBLISHED
  • APRIL 2019 Issue has been successfully launched on 1 April 2019

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Abstract

FORMULATION AND EVALUATION OF FAST DISSOLVING SUBLINGUAL FILMS OF SERTRALINE HCL

M. Sudheer Kumar*, P. Srilatha, P. Ganesh, S. Lakshmi, Md. Reshma, K. Uma Maheswara Rao, N. Ramya, Kumar Raja Jayavarapu and T. Satyanarayana

ABSTRACT

The present study is aimed to prepare sublingual dosage forms of the seretraline Hcl with the purpose to achieve quick onset of action in management of antidepressant. Fast dissolving sublingual films of seretraline Hcl were thus prepared by solvent casting method water soluble polymer HPMC E15 was used as film forming polymer. poly ethylene glycol 400 and glycerin were used as plasticizer. Sucralose was added as a sweetener and peppermint oil as flavouring agent. The formulation prepared were evaluated for their uniformity of weight, surface pH, folding endurance, disintegration time, mucoadhesion time, tensile strength, %elongation, content uniformity and %drug release. The FTIR studies showed no interaction between drug and polymer. From the observation of evaluation results, it was concluded that formulation F3 containing PEG400 and glycerin for films prepared using HPMC E15was the best formulation among all other formulation. Films showed excellent stability when kept at RT as well as at 400Âșc and 75% RH.

Keywords: sertraline HCl, fast dissolving sublingual film, film forming polymer HPMC E15.


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