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  • WJPPS APRIL ISSUE PUBLISHED
  • APRIL 2019 Issue has been successfully launched on 1 April 2019

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

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  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
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  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
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Abstract

REVIEW ARTICLE ON ORAL DISINTEGRATION TABLETS

Savithri T. B.*, Kavitha S. K. and M. Gnana Ruba Priya

ABSTRACT

The desire of improved palatability in orally administered products has prompted the development of numerous formulations with improved performance and acceptability. Orally disintegrating tablets are an emerging trend in novel drug delivery system and have received ever-increasing demand during the last few decades. The field has become a rapidly growing area in the pharmaceutical industry and gaining popularity due to ease of administration and better patient compliance especially for geriatric and pediatric patients. ODTs are solid unit dosage forms, which disintegrates or dissolves rapidly in the mouth without chewing and water. This type of property in dosage form can be attained by addition of different excipients, from which disintegrated is the key adjuvant. In recent years, several newer agents have been developed known as superdisintegrants. Diverse categories of superdisintegrants such as synthetic, semi-synthetic, natural and co processed blends etc. have been employed to develop effectual mouth dissolving tablets and to overcome the limitations of conventional tablet dosage forms. The objective of the present article is to highlight the various kinds of superdisintegrants along with their role in tablet disintegration and drug release, which are being used in the formulation to provide the safer, effective drug delivery with patient compliance. This review focuses on various synthetic superdisintegrants, natural superdisintegrants from different plant sources, co-processed excipients blend and their efficiency.

Keywords: Orally disintegrating tablet, superdisintegrants, excipients, formulation, dissolution.


[Full Text Article]

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