Abstract

REVIEW: INJECTABLE TISSUE PATCHES FOR HEART REPAIR

Shanisha Mehetre*, Dr. Mrs.Manisha Karpe and Dr. Vilasrao Kadam

ABSTRACT

Background: Injectable tissue patches provide effective minimally invasive approach for recovery of heart muscles. The aim of this paper is to study the advantages and disadvantages of injectable tissue patches and highlight their potential applications for myocardium repair. Overview: Cardiovascular disease is prime cause of death worldwide. Since postnatal cardiomyocytes displays no regenerative capacity, myocardium damages often develop into scar tissues and causes heart dilatation and failure. Except for heart transplantation, there are no sufficiently good treatments available for heart failure. Since heart muscles do not have any replacement alternatives like heart valves, there is need to create/regenerate engineered heart muscle using cardiovascular tissue engineering. Due to declining donor supply, the gap between supply and demand for heart replacement therapies has been increased. As a result a alternative invention was generated in the field of drug delivery to the heart. Conclusion: Injectible tissue patches help to repair diseased and injured heart. Different approaches have been used for scaffold synthesis and fabrication. The patches thus produced through this approaches showed significant improvement in the functioning of heart.

Keywords: Engineered tissue, Cardiac patch, Decellularized tissue, Induced pluripotent stem cells, Cardiomyocytes, Extracellular matrix.