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  • WJPPS MARCH ISSUE PUBLISHED
  • MARCH 2019 Issue has been successfully launched on 1 March 2019

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  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

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Abstract

HEPATORENAL PROTECTIVE EFFECT OF CURCUMIN IN NORMAL AND INFECTED RATS WITH STAPHYLOCOCUSS AUREUS TREATED WITH AZITHROMYCIN

*M. G. A. EL. Sayed, Enas A. H. Farag and Mona Y. M. Kandil

ABSTRACT

The aim of this study was to determine the adverse effects of therapeutic dose of azithromycin 45 mg /kg body weight for 5 days in normal, and infected rats with staphylococcus aureus on liver and kidney functions. Forty five male Wister albino rats were randomly divided into main five groups including Group(1): control(normal saline only 0.2ml). Group (2):rats treated with azithromycin orally(45 mg/kg b.wt) for 5 successive days. Group (3): rats were infected with Staphylococcus aureus. Group (4): rats were infected with Staphylococcus aureus and treated with azithromycin (45 mg/kg b.wt) daily for 5 successive days. Group (5): rats were infected with Staphylococcus aureus and treated with azithromycin orally (45 mg/kg b.wt) plus curcumin (20mg/kg b.wt) daily for 5 successive days. Treatment with azithromycin showed a significant (P<0.05) decrease of albumin level while the levels of serum transaminase (ALT and AST), alkaline phosphate (ALP), total bilirubin, direct bilirubin, urea and creatinine were significantly increased. Otherwise rats administered azithromycin and curcumin showed a significant increase in albumin level and a significant decrease of serum transaminase (ALT and AST), alkaline phosphatase (ALP), total bilirubin, direct bilirubin, urea and creatinine when compared with rats treated with azithromycin. Histopathological examinations of liver and kidney tissues confirmed the biochemical results. It is concluded that The administrations of therapeutic dose of azithromycin 45 mg /kg b.wt induced marked liver and renal damage. Supplementation of curcumin showed improvement in liver and kidney function.

Keywords: azithermycin –curcumin-biochemical-histopathological.


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