Abstract

PHARMACOKINETIC OF FOSFOMYCIN IN HEALTHY AND ESCHERICHIA COLI INFECTED BROILER CHICKEN

M. G. A. El-Sayed, Enas A. H. Farag and Doaa S. A. Farag*

ABSTRACT

In the present work, the pharmacokinetic parameters of fosfomycin after intravenous and oral administration in normal and experimentally infected chicken were studied in fourty clinically normal Habard chickens (9 normal and 5 experimentally infected chicken). Chickens were divided into 3 groups. The bioavailability of fosfomycin was calculated in normal chicken. The disposition kinetics as well as the tissue residues after repeated administration of fosfomycin once daily for five consecutive days in normal and experimentally infected chicken were studied. Following a single intravenous injection of 80 mg fosfomycin/kg b.wt. in normal chickens, the drug could be detected therapeutically till 24 hours post intravenous injection with value equal to 2.03 μg/ml. The serum concentration time curve of fosfomycin following intravenous injection showed that the drug obayed a first order two-compartments open model. Fosfomycin after intravenous dose revealed a rapid distribution phase (α =0.567h-1) with a distribution half-life (t0.5(α)) of 1.23h. The apparent volume of distribution by steady-state method (ml/kg), [V(dss)] method was 1.63l/kg. Fosfomycin was transferred from central to peripheral compartment [K12] at slower rate (0.169 h-1) than its passage from peripheral to central compartment [K21] (0.1783 h-1). Fosfomycin was decreased after intravenous injection with a half-life [t0.5(β)] value of 7.06 hours and cleared by all clearance processes in the body at a rate of 0.26 l/kg/h.

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