Abstract

FORMULATION OF FAST DISSOLVING TABLETS OF MELOXICAM USING SOLID DISPERSION METHOD

Sana Saleh Al-Kubati* and Ahmed Mohammed Othman

ABSTRACT

In the present work, an attempt was made to prepare fast dissolving tablets containing meloxicam solid dispersions with the aim to enhance its dissolution rate. Meloxicam solid dispersions (MSDs) with polyvinyl pyrrolidone (PVP) in different ratios were prepared by solvent evaporation method. The MSDs was mixed with other excipients and compressed into tablets by direct compression method. The prepared tablets were evaluated for various pharmaceutical characteristics such as hardness, friability, weight variation, thickness, disintegration time, drug content, and in vitro drug release. All the formulated tablets were within the acceptable limits. Among the tablet formulations, formula F-1 containing SD of meloxicam to PVP in ratio of 1:1 showed short disintegration time of almost 34 sec and about 57.92% , 85.76% and 104.62% of drug release after 2, 15 and 30 minutes respectively which was much higher than those tablets prepared without PVP (F-0) and marketed products. It was concluded that the prepared solid dispersions with PVP as a hydrophilic carrier was a suitable method to enhance the dissolution of meloxicam.

Keywords: Meloxicam, solid dispersion, enhanced dissolution, fast dissolving tablets.