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  • WJPPS MARCH ISSUE PUBLISHED
  • MARCH 2019 Issue has been successfully launched on 1 March 2019

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Abstract

PREPARATION AND CHARACTERIZATION OF SIMVASTATIN SOLID DISPERSIONS BY SPRAY DRYING TECHNIQUE

Shinde Sunita S.*, Desai Sanjeevani R., Dhumal Gorakh J., Mevekari Fatima I. and Mevekari Anjum I.

ABSTRACT

The objective of the present study was to formulate solid dispersions (SD) of simvastatin to improve the aqueous solubility and dissolution rate to facilitate faster onset of action. Simvastatin is a BCS Class II drug having low solubility (1.45 μg/mL) and therefore low oral bioavailability (5%). In the present study, SDs of simvastatin different drug–carrier ratios was prepared by a spray drying method. solid dispersions were characterized by differential scanning calorimetry (DSC), powder x-ray diffractometry (PXRD), scanning electron microscopy (SEM), and infrared spectroscopy (IR) and evaluated for drug content, saturation solubility, the PXRD study demonstrated that there was a significant decrease in crystallinity of pure drug present in solid dispersions, which resulted in an increased dissolution rate of simvastatin. Formulation is optimized on the basis of acceptable solid dispersion properties and in-vitro release.

Keywords: Simvastatin, drug release, Solid dispersion.


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