Abstract

FORMULATION AND INVITRO EVALUATION OF SUMATRIPTAN SUCCINATE FAST DISSOLVING TABLETS

Mohammad Asif*, M. A. Rehman Vineela Sangu K. Divyaakshmi

ABSTRACT

Fast Dissolving Tablets are solid unit dosage forms, which disintegrate or dissolve rapidly in the mouth without chewing and water. FDTs or orally disintegrating tablets provide an advantage particularly for pediatric and geriatric populations who have difficulty in swallowing conventional tablets and capsules. The present dissertation work is an attempt to select the best possible diluents- disintegrant combination to formulate rapidly disintegrating tablets of Sumatriptan Succinate, which disintegrates in matter of seconds in the oral cavity, thereby reducing the first-pass metabolism and the time of onset of pharmacological action. The percentage drug content of all the tablets was found to be between 97.12±0.280% and 99.25±0.670% of Sumatriptan Succinate, which was within the acceptable limits.

Keywords: Disintegrants, conventional tablets, first pass metabolism.