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Abstract

A COMPARATIVE STUDY OF CEFOTAXIME AND CEFTRIAXONE IN SURGICAL PROPHYLAXIS FOR CLEAN HERNIA SURGERY

Dr. G. Ravishankar*, S. Rajarajan M. Pharm, Lekshmi R. Nair, Sinu M. Saju, Dr. V. Ganesan and M. Pharm PhD

ABSTRACT

Background: The defect in the collagen metabolism is involved in the pathogenesis of hernia which lead to a weakening of the transversalis fascia. Hernia is the most common surgery performed by general surgeons and which have many advantages, such as effectiveness, simplicity, minimal pain, and low recurrence rates, early return to work and a high patient satisfaction. In which Lichtenstein technique is frequently used method. Objective: To conduct a comparative study of cefotaxime and ceftriaxone in surgical prophylaxis for clean hernia surgery. Patient and Methods: An experimental prospective study conducted over a period of 8 months from 2017-2018. In which 100 patients were divided into two groups. The cases were compared on the basis of age, ASA grading, gender, comorbidities, radiological assessment which directly or indirectly affect the occurrence of surgical site infections were also considered. Furthermore; Chi-square test has been used to find out the statistical significant relation. Result: We found that, 100 patients were divided into two groups. The patients 50-59years(26%) were more prone to hernia than those ranging from <30(11%) years. According to our study male (72%) were to exposed to hernia as compared with female (28%), were as female are more susceptible to SSI’s. Out of 100 patients 20 patients(20%) diagnosed with Direct hernia 40 patients (40%) diagnosed with Indirect hernia. Also hernia was located in the right side in 56 patients (93%) whereas14 (33%) patients had the hernia located in the left side. In our study, surgical site infection in ceftraxone was 1%a nd that in cefotaxime was 3% .By using Southampton Wound Assessment Scale. It was found that where erythema is a grade 1A. Conclusion: This study was done to measure incidence of surgical site infection in Open Mesh Hernioplasty using single dose of Ceftriaxone 1g and Cefotaxime1g.According to southamptone wound gradeing system, where erythema is a grade 1A was observed and it was concluded that ceftriaxone was better as compared to cefotaxime for preventing surgical site infection.

Keywords: Cefotaxime, Ceftriaxone, Hernia, Lichtenstein technique.


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