Abstract

ORAL SUSTAINED DELIVERY OF GASTROPROKINETIC DRUG MOSAPRIDE CITRATE FROM FLOATING MATRIX TABLETS-FORMULATION AND IN VITRO CHARACTERIZATION

Manal Yassien Hamza*

ABSTRACT

Floating drug delivery systems can significantly prolong the gastric residence time of drug providing continuous input and greater therapeutic efficacy of the drug. The aim of the present study was to formulate effervescent floating tablets of Mosapride citrate by direct compression method; using hydrophilic swellable carriers such as polyethylene oxide PEO WSR 1105, PEO WSR 301and PEO WSR 303 as a release retarding agent, Sodium starch glycolate as swelling enhancer and sodium bicarbonate as a gas generating agent. The effervescent floating tablet formulations were evaluated for physicochemical properties, in vitro buoyancy, drug release, rate order kinetics and stability studies. Result revealed that, F11 (WSR 303, 30 %) was selected as an optimized formulation based on its 12 hr drug release (80.3% at the end of 12 hr) with minimal floating lag time(0-0.2min), maximum total floating time (> 12 hr.) The optimized formulation followed zero order rate kinetics, non- Fickian diffusion mechanism. Furthermore, The accelerated stability studies, at 400 C / 75% RH, of the optimized formulation was carried out for three months and no significant changes were observed.

Keywords: Mosapride citrate; effervescent Floating tablets; Polyethylene oxide; Release kinetics.