Photo Gallery

Login

Search

News & Updation

  • WJPPS FEBRUARY ISSUE PUBLISHED
  • FEBRUARY 2019 Issue has been successfully launched on 1 February 2019

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  

Abstract

FORMULATION AND EVALUATION OF DOXOFYLLINE BUCCAL PATCHES

Dr. Jayapal reddy Gangadi*, Dr. Sanjeev Kumar Subudhi, T. Sameera Devi, Ch. Akhila, Sushma, M. Sandeep and D. Arun kumar

ABSTRACT

The objective of present study was to develop matrix type buccal patch therapeutic systems of Doxofylline using sodium alginate, ethylcellulose, and hydroxypropyl methylcellulose in various proportions and combinations were fabricated by solvent casting technique. Various physicomechanical parameters like weight variation, thickness, folding endurance, drug content, moisture content, moisture absorption, in vitro drug release studies were evaluated. An in vitro drug release study was designed, and it was carried out using commercial semipermeable membrane. The F4 formulation was found to be stable as there was no drastic change in the Physico-chemical properties of the patches. F1, F2, F3, F4 formulations showed highest cumulative percentage drug release of 97.35%, 95.35%, 94.26%, 98.60%. were obtained during in vitro drug release studies after 20 hrs. The release of Doxofylline appears to be dependent on lipophilicity of the matrix. Moderately lipophillic matrices showed best release. The predominant release mechanism of drug through the fabricated matrices was believed to be by diffusion mechanism. Based upon the in vitro dissolution data the F4 formulation was concluded as optimized formulation.

Keywords: Buccal delivery system, Natural and synthetic polymers, solvent casting technique, Diffusion mechanism.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More