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  • WJPPS APRIL ISSUE PUBLISHED
  • APRIL 2019 Issue has been successfully launched on 1 April 2019

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
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  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
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Abstract

FEBUXOSTAT INHIBITS CONCANAVALIN A INDUCED ACUTE HEPATIC INJURY IN MICE AS INDICATED BY DECREASING THE INCREASED SERUM TRANSAMINASE, TOTAL BILIRUBIN AND ALBUMIN

Mohammed M. Maresh*, Rania R. Abdelaziz, Aya A. Shalaby and Tarek M. Ibrahim

ABSTRACT

Effect of febuxostat administration on acute liver injury induced by concanavalin A injection into mice eye orbital sinus was studied in the present work. Oral administration of febuxostat either 1 hours before administration of Con A or ½ hour after administration of Con A both significantly inhibited the increase of serum ALT, AST, total bilirubin, and the decrease of serum albumin induced by Con A. These results indicate that febuxostat may be an effective inhibitor of the immune reaction that results from Con A administration into mice.

Keywords: Acute Hepatic Injury, Concanavalin A, Febuxostat.


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