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Abstract

SIMULTANEOUS ESTIMATION OF AMLODIPINE BESYLATE AND PERINDOPRIL ERBUMINE IN COMBINED DOSAGE FORM BY RP-HPLC

Tribhuvan Singh1*, Jogu Chandrudu, J. Dinesh Babu1, Mihir Y. Parmar and Chidirala Suresh

ABSTRACT

The present work was developed and validated an analytical method for quantitative determination of Perindopril Erbumine and Amlodipine Besylate in a tablet formulation. Chromatographic separation of the two drugs was achieved on an Eclipse XDB C-8 (150 mm X 4.6 mm), 5mm. The mobile phase constituted of Buffer: Acetonitrile (65:35) and pH adjusted to 2.6 with dilute Ortho- Phosphoric Acid was delivered at the flow rate 1.0 mL/min. Detection was performed at 210 nm. Separation was completed within 8 min. The retention time for Perindopril Erbumine and Amlodipine Besylate 3.168 & 5.504 min respectively. Calibration curves were linear with correlation coefficient between 0.99 to 1.0 over a concentration range of 8 to 60 mg/mL of Perindopril Erbumine and 10 to 75 mg/mL of Amlodipine Besylate. The relative standard deviation (RSD) was found< 2.0%.

Keywords: Perindopril Erbumine; Amlodipine Besylate; Reversed-phase HPLC.


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