Photo Gallery

Login

Search

News & Updation

  • WJPPS FEBRUARY ISSUE PUBLISHED
  • FEBRUARY 2019 Issue has been successfully launched on 1 February 2019

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  

Abstract

A VALIDATED RP-HPLC METHOD FOR PRASUGREL HYDROCHLORIDE

D. Pavan Kumar*, T. Naga Jhansi, G. Srinivasa Rao and Kirti Kumar Jain

ABSTRACT

Prasugrel hydrochloride, (2S)-4-Oxo-[3-(trifluromethyl)-5,6-dihydro[1,2,4]triazolo [4,3-α] pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butane-2-amine is a platelet inhibitor and an irreversible antagonist of P2Y12 ADP receptors and is used for the treatment of heart patients to prevents from forming harmful blood clots. Several bio-analytical and analytical methods have been reported for the analysis of Prasugrel hydrochloride. Recently stability indicated related substance by HPLC method was published in European Pharmacopoeia and United States Pharmacopeia, with six potential impurities.[1-2] Three of the in-house process impurities were not separated by pharmacopeia method. So, comprehensive study was taken to develop a single method for all these impurities and it should be stability indicating method. In this newly developed HPLC method included three in-house impurities other than the listed pharmacopeia impurities. This method is accurate, linear, specific, reproducible and stability indicating HPLC method with good Limit of Quantification and Limit of Detection of Prasugrel hydrochloride and its related impurities.

Keywords: .


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More