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  • WJPPS FEBRUARY ISSUE PUBLISHED
  • FEBRUARY 2019 Issue has been successfully launched on 1 February 2019

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
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  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
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Abstract

MOLECULAR AND IN SILICO STUDIES ON DHFR OF UROPATHOGENIC KLEBSIELLA PNEUMONIAE

Archana Moon*, Deeba Khan, Pranjali Gajbhiye, Monali Jariya and Amit aksande

ABSTRACT

The most common uropathogenic Gram negative bacteria are Escherichia coli and Klebsiella pneumoniae. MDR Klebsiella infection poses a significant challenge for treatment. K. pneumoniae strains have become increasingly resistant to antibiotics, rendering infection by these strains very challenging to treat. Dihydrofolate reductase (DHFR) has been a target for treatment against a variety of pathogenic microorganisms, since the folate-dependent enzymes are essential for DNA synthesis and methylation. This study was designed to study promising antibacterial molecules viz; Chlorogenic acid, Hippuric acid, Ellagic acid, Gallic acid and Quercetin as alternatives to antibiotics. Antibiotic and molecular studies on Klebsiella pneumoniae were performed. Further, molecular docking using AutoDock, an automated suite of proteinligand docking tools was used to identify potent antibacterial compounds to treat Klebsiella pneumonia mediated UTI.

Keywords: Antibacterial activity, Chlorogenic acid, Hippuric acid, Ellagic acid, Gallic acid, Quercetin, DHFR, Molecular Docking, MDR, UTI.


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